Monday, 16 June 2025

What is DiGeorge Syndrome?

 


DiGeorge syndrome is a genetic condition that happens when a small part of chromosome 22 is missing. This missing piece affects how different parts of the body grow and work.


How Does It Happen?

It’s caused by a deletion (missing section) in chromosome 22 at position q11.2.

It can happen by chance (randomly) or be passed on from a parent.


Common Signs and Symptoms

People with DiGeorge syndrome may have a wide variety of symptoms. These can range from mild to serious, and not everyone has the same problems.

💓 Heart Problems

Many babies are born with heart defects, especially in the areas where blood leaves the heart.

🛡️ Weak Immune System

The thymus gland, which helps fight infection, might be missing or small.

This can cause more frequent infections.

👄 Mouth and Face Differences

Cleft palate (a hole in the roof of the mouth)

Facial features may include a long face, small chin, or ears that are set low.

⚖️ Low Calcium (Hypocalcemia)

Problems with the parathyroid glands can cause low calcium levels, which may lead to seizures or muscle cramps.

🧠 Learning and Development

Some people may have learning difficulties, delays in speech, or trouble with attention or behavior.


How Is It Diagnosed?

A genetic test (blood test) looks for the missing part of chromosome 22.

Sometimes it’s found during tests for heart problems or delays in growth and learning.


Is There a Cure?

There is no cure, but many treatments are available to help manage symptoms.

This might include:

Heart surgery

Calcium supplements

Immune system support

Speech, physical, and educational therapy


Living with DiGeorge Syndrome

People with this condition can live full lives with the right support.

Early diagnosis and care make a big difference in managing health and development.


 

 


 

 

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